Invention Grant
- Patent Title: Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK
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Application No.: US18308813Application Date: 2023-04-28
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Publication No.: US12135329B2Publication Date: 2024-11-05
- Inventor: Jiang Wu , Guodong Zhang , Daniel J. Sexton , Ryan Faucette , Gul M. Mustafa , Mark Szewc
- Applicant: Takeda Pharmaceutical Company Limited
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: G01N33/68
- IPC: G01N33/68 ; G01N30/72 ; G01N30/88 ; G01N30/02
Abstract:
Methods for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK in a sample are provided herein. Such methods may comprise treating a biological sample with a protease to generate a plurality of digested peptides, and measuring one or more signature peptides, which are indicative of cleaved HMWK and/or full-length HMWK.
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