A wearable and reconfigurable motion assistance apparatus may include: a waist belt to be worn around a waist part of a user, a thigh belt to be worn around a thigh part of the user, an actuator connected to the waist belt and configured to generate power, a main frame including an upper frame connected to the actuator and a lower frame connected to the upper frame and configured to transmit the power to the thigh belt, an upper cover provided to be detachable from the upper frame, and a lower cover provided to be detachable from the lower frame.