New and useful systems, apparatuses, and methods for providing negative-pressure therapy with instillation of topical treatment solutions are described. An apparatus may comprise an exudate container, a solution source, and a pneumatically-actuated instillation regulator. The instillation regulator may be coupled to the exudate container and to the solution source, and negative pressure from a negative-pressure source can actuate the instillation regulator. In some embodiments, a negative-pressure source may be configured for a negative-pressure interval and a venting interval, and the instillation regulator can be configured to draw instillation solution from the solution source during a negative-pressure interval and to instill the solution to a dressing during a venting interval.