An exemplary method includes accessing information associated with a power supply connection between a plurality of power distribution units and a plurality of power converters of a data center appliance, determining, based on the information, a current power connection topology of the plurality of power converters of the data center appliance with respect to the plurality of power distribution units, analyzing the current power connection topology to determine whether the current power connection topology satisfies predefined operating parameters for the data center appliance and the plurality of power distribution units, and performing, based on the analyzing of the current power connection topology, an action associated with the power supply connection between the plurality of power converters and the plurality of power distribution units.