Methods, systems, and apparatuses are provided for enhancing timing alignment for uplink (UL) multi-Transmission/Reception Point (TRP) (or mTRP) scenarios in a wireless communication system. A method for a UE in a wireless communication system can comprise receiving a signaling, wherein the signaling indicates activation for a first TRP and/or is a Physical Downlink Control Channel (PDCCH) signal, determining to perform a first random access procedure on the first TRP, based on the signaling, to obtain a first Time Alignment (TA) information associated with the first TRP, and performing multi-TRP operation on the first TRP associated with the first TA information and a second TRP associated with a second TA information.