A system for color gamut normalization for pathology slides, the system including at least computing device, wherein the computing device is configured to receive a whole slide image, generate a plurality of segments associated with the whole slide image as a function of one or more biological tissue type variabilities, apply a segment-specific transformation to each segment of the plurality of segments, create a user interface data structure, wherein the user interface data structure includes the plurality of segments and display the plurality of segments through a graphical user interface as a function of the user interface data structure.