A pixel driving circuit, a driving method thereof, and a display panel are disclosed. A second transistor stores a threshold voltage of a first transistor in a first capacitor according to a second scan signal, so as to compensate an influence of the threshold voltage on a driving current. A fifth transistor makes a voltage difference between a first node and a second node irrelevant to a second voltage signal according to a fourth scan signal, so as to improve a current attenuation issue caused by a voltage drop during a signal transmission.