Embodiments of the present disclosure relate to generation and detection of physical random access channel (PRACH) preamble. A first device determines a base sequence, a first scrambling sequence for the base sequence, and a second scrambling sequence for the base sequence. The first device generates a random access preamble by applying the first and second scrambling sequences to different portions of the base sequence, respectively. The first device transmits the random access preamble to a second device.