A motor-driven compressor includes a rotary shaft, an electric motor, a compression unit, an inverter, a housing, and an inverter case. The housing includes a housing end wall and a housing circumferential wall, which extends from a housing end wall in an axial direction of the rotary shaft. The inverter case includes a case end wall, which extends in the axial direction from the case end wall. The seal circumferential wall includes a proximal end connected to the case end wall and an end face located at a distal end. The housing circumferential wall includes an opposed surface that is opposed to the end face. An annular seal member is provided between the seal circumferential wall and the housing circumferential wall. The seal member extends in a radial direction of the rotary shaft between the end face and the opposed surface.