A mute-able input device with keystroke tactile feedback includes: a plurality of keys, each including a tactile structure and a sound-generating structure for respectively generating operational tactile feedback and operating sounds; a plurality of adjusting mechanisms, each including an adjusting portion corresponding to one of the keys; at least one switching unit including an operating portion and a switch member, the operating portion connecting the switch member and the adjusting mechanism, the switch member generating a switching signal involving a mode switching between different tactile modes or different sound modes for one or more keys. When the operating portion moves in response to a force, the switch member is triggered to achieve the mode switching; meanwhile, the adjusting portion moves to interfere with at least one of the tactile structure or the sound-generating structure along with the movement of the operating portion.