A display substrate and a display device are provided. The display substrate includes a base substrate, first color sub-pixels, data lines, and first power signal lines located on the base substrate. Each first color sub-pixel includes an organic light emitting element including a first electrode, a light emitting layer and a second electrode. The data lines are located between the second electrode and the base substrate. The first power signal lines are disposed in the same layer as the data lines. The display substrate further includes a first pad block disposed in the same layer as the data lines; the second electrode of each first color sub-pixel is overlapped with the data line, the first power signal line and the first pad block; and the first power signal line and the first pad block are located at both sides of the data line.