An electronic device, a trusted application calling method and apparatus, a device, and a medium are disclosed. Because a trusted application development platform is linked with native trusted applications respectively corresponding to multiple trusted execution environment operating systems (TEE OS), based on the trusted application development platform, a bytecode trusted application can be applicable to any TEE OS, and for different TEE OS hardware platforms, only one corresponding bytecode trusted application needs to be developed for one application. Moreover, the trusted application development platform and the byte code trusted application can be applied to electronic devices (terminals) of different TEE OSs.