Systems/techniques that facilitate deep learning multi-planar reformatting of medical images are provided. In various embodiments, a system can access a three-dimensional medical image. In various aspects, the system can localize, via execution of a machine learning model, a set of landmarks depicted in the three-dimensional medical image, a set of principal anatomical planes depicted in the three-dimensional medical image, and a set of organs depicted in the three-dimensional medical image. In various instances, the system can determine an anatomical orientation exhibited by the three-dimensional medical image, based on the set of landmarks, the set of principal anatomical planes, or the set of organs. In various cases, the system can rotate the three-dimensional medical image, such that the anatomical orientation now matches a predetermined anatomical orientation.