A refrigerator includes a transparent panel assembly. The transparent panel assembly includes a front panel defining at least a part of a front appearance of a refrigerator door and made of a glass material, a rear panel defining at least a part of a rear appearance of the refrigerator door and made of a transparent material, and an intermediate member connected between the front panel and the rear panel and made of a transparent plastic member. The intermediate member includes an edge portion having both ends connected to a screening area formed at peripheries of the front panel and the rear panel, and a partition portion formed to cross an inner surface of the edge portion to partition a gap between the front panel and the rear panel to thereby form a sealed insulation layer.