Invention Application
- Patent Title: Method for the preparation of citalopram
- Patent Title (中): 西酞普兰制备方法
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Application No.: US10012054Application Date: 2001-11-06
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Publication No.: US20020077353A1Publication Date: 2002-06-20
- Inventor: Hans Petersen , Michael Harold Rock , Henrik Svane
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby-Copenhagen
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby-Copenhagen
- Priority: DKPA199900920 19990625
- Main IPC: C07D307/78
- IPC: C07D307/78 ; A61K031/343
Abstract:
Method for the preparation of citalopram comprising reaction of a compound of Formula (IV) 1 wherein R is halogen, or CF3null(CF2)nnullSO2null, n being 0 to 8, with a cyanide source in the presence of a palladium catalyst and a catalytic amount of Cnull or Zn2null, or with Zn(CN)2 in the presence of a palladium catalyst.
Information query
