- 专利标题: Process for the preparation of pharmaceutically active thiazolidine or oxazolidine compounds by a yeast reductase
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申请号: US09973970申请日: 2001-10-09
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公开(公告)号: US20020106762A1公开(公告)日: 2002-08-08
- 发明人: Richard Mark Hindley , Stefan Roland Woroniecki
- 申请人: Smith Kline Beecham plc
- 申请人地址: null
- 专利权人: Smith Kline Beecham plc
- 当前专利权人: Smith Kline Beecham plc
- 当前专利权人地址: null
- 优先权: GB9124513.4 19911119
- 主分类号: C12P017/14
- IPC分类号: C12P017/14 ; C12P017/10
摘要:
1 A process for preparing a compound of formula (I), or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof and/or a pharmaceutically acceptable solvate thereof, wherein: T represents a substituted or unsubstituted aryl group and T1 is O or S; which process comprises, treating a compound of formula (II), or a tautomeric form thereof and/or a salt thereof and/or a solvate thereof, wherein T and T1 are as defined in relation to formula (I), with a microbial reductase obtained from an appropriate red yeast; and thereafter, as required, preparing a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I) or a tautomeric form thereof; compounds prepared by such a process and the use of such compounds in medicine.
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