Invention Application
- Patent Title: Method for the preparation of pure citalopram
- Patent Title (中): 纯西酞普兰的制备方法
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Application No.: US10046126Application Date: 2002-01-08
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Publication No.: US20020120005A1Publication Date: 2002-08-29
- Inventor: Marco Villa , Federico Sbrogio , Robert Dancer
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby-Copenhagen
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby-Copenhagen
- Priority: DKPA200001929 20001222
- Main IPC: A61K031/36
- IPC: A61K031/36 ; C07D37/81

Abstract:
The present invention relates to the process for the preparation and purification of citalopram (I) 1 in which a compound of formula (II) 2 wherein Z is iodo, bromo, chloro or CF3null(CF2)nnullSO2nullOnull, n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction with a cyanide source; the resultant crude citalopram product is optionally subjected to some initial purification and subsequently treated with an amide or an amide-like group forming agent; the reaction mixture is then subjected to an acid/base wash and/or crystallisation and recrystallisation of citalopram in order to remove the amides formed from the crude citalopram mixture; and the resulting citalopram product is optionally further purified, worked up and isolated as the base or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US06455710B1 Method for the preparation of pure citalopram Public/Granted day:2002-09-24
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