A system and method for mass spectrometry in which the system includes at least one ion source which produces ions, a mass spectrometer having an inlet orifice configured to accept the ions, and a capillary ion delivery device which detachably interfaces to the inlet orifice of the mass spectrometer. The method includes producing ions from the ion source, transporting the ions from the ion source to the inlet orifice of the mass spectrometer via the capillary ion delivery device, and mass analyzing the ions in the mass spectrometer.