Hepatocyte growth factor receptor antagonists and uses thereof

Invention Application

US20020136721A1 Hepatocyte growth factor receptor antagonists and uses thereof 审中-公开

Title translation: 肝细胞生长因子受体拮抗剂及其用途

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Patent Title: Hepatocyte growth factor receptor antagonists and uses thereof
Patent Title (中): 肝细胞生长因子受体拮抗剂及其用途
Application No.: US09995693

Application Date: 2001-11-29
Publication No.: US20020136721A1

Publication Date: 2002-09-26
Inventor: Ralph H. Schwall , Kelly H. Tabor
Main IPC: A61K039/395
IPC: A61K039/395 ; C07H021/04 ; C12P021/02 ; C12N005/06 ; C07K016/28

Hepatocyte growth factor receptor antagonists and uses thereof

Abstract:

Hepatocyte growth factor (HGF) receptor antagonists are provided. The HGF receptor antagonists include HGF receptor antibodies and fragments thereof. The HGF receptor antagonists can be employed to block binding of HGF to HGF receptors or substantially inhibit HGF receptor activation. The HGF receptor antagonists may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treating cancer using the HGF receptor antagonists are also provided.

Abstract(Chinese):

提供肝细胞生长因子（HGF）受体拮抗剂。 HGF受体拮抗剂包括HGF受体抗体及其片段。 HGF受体拮抗剂可用于阻断HGF与HGF受体的结合或基本上抑制HGF受体活化。 HGF受体拮抗剂可以包括在药物组合物，制品或试剂盒中。还提供了使用HGF受体拮抗剂治疗癌症的方法。

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