Invention Application
- Patent Title: Stabilized pharmaceutical composition
- Patent Title (中): 稳定的药物组合物
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Application No.: US10079958Application Date: 2002-02-19
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Publication No.: US20020137771A1Publication Date: 2002-09-26
- Inventor: Tadashi Makino , Tetsuro Tabata , Shin-Ichiro Hirai
- Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD.
- Applicant Address: JP OSAKA
- Assignee: TAKEDA CHEMICAL INDUSTRIES, LTD.
- Current Assignee: TAKEDA CHEMICAL INDUSTRIES, LTD.
- Current Assignee Address: JP OSAKA
- Priority: JP1986-29567 19860213; JP1986-38059 19860212; JP29567/1986 19860213; JP38059/1986 19860221
- Main IPC: A61K031/4439
- IPC: A61K031/4439 ; B01J013/00

Abstract:
The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula 1 wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
Public/Granted literature
- US06521256B2 Stabilized pharmaceutical composition Public/Granted day:2003-02-18
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