Invention Application
US20030125280A1 Tissue specific and target RNA-specific ribozymes as antimicrobial therapeutics against microbial pathogens
审中-公开
组织特异性和靶RNA特异性核酶作为抗微生物病原体的抗微生物治疗剂
- Patent Title: Tissue specific and target RNA-specific ribozymes as antimicrobial therapeutics against microbial pathogens
- Patent Title (中): 组织特异性和靶RNA特异性核酶作为抗微生物病原体的抗微生物治疗剂
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Application No.: US10127025Application Date: 2002-04-19
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Publication No.: US20030125280A1Publication Date: 2003-07-03
- Inventor: James S. Norris , Michael G. Schmidt , Joseph W. Dolan , Steven D. London , Harold D. May , Gary A. Clawson
- Applicant: Medical University of South Carolina , The Penn State Research Foundation, a Pennsylvania corporation
- Applicant Address: null null
- Assignee: Medical University of South Carolina,The Penn State Research Foundation, a Pennsylvania corporation
- Current Assignee: Medical University of South Carolina,The Penn State Research Foundation, a Pennsylvania corporation
- Current Assignee Address: null null
- Main IPC: A61K048/00
- IPC: A61K048/00 ; A61K009/127 ; C12N015/86 ; C12N015/88 ; C12N007/00
Abstract:
The invention provides compositions comprising the tissue specific and target RNA-specific ribozyme(s) in either a viral delivery system or a biologic liposome preparation, wherein the viral delivery system or a biologic liposome comprises a pathogen-specific promotor upstream from a sequence encoding a triple ribozyme comprising a) a 5null autocatalytically cleaving ribozyme sequence, b) a catalytic ribozyme comprising a target RNA-specific binding site and c) a 3null autocatalytically cleaving ribozyme sequence. The invention also provides methods of treating and/or preventing bacterial infections by administering the compositions of the invention.
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