发明申请
- 专利标题: Vectors for tissue-specific replication
- 专利标题(中): 用于组织特异性复制的载体
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申请号: US10323984申请日: 2002-12-19
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公开(公告)号: US20030129175A1公开(公告)日: 2003-07-10
- 发明人: Paul L. Hallenbeck , Yung-Nien Chang , Yawen L. Chiang
- 主分类号: A61K048/00
- IPC分类号: A61K048/00 ; C12N015/86 ; C12N005/08
摘要:
The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and methods for using them. Such vectors are able to selectively replicate in a target tissue to provide a therapeutic benefit from the presence of the vector per se or from heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated.