A reconfigurable orthopedic sleep aid that is adapted to be worn by a patient about the hips and legs, a knee, a portion of the back, a shoulder, and or another symptomatic anatomical location for injury prevention, trauma amelioration, and optimized comfort, and when applicable for reduced periods of post-trauma convalescence. The sleep aid incorporates a stretchable, stretchably conformable, or loose fitting garment, such as a girdle or trouser that is adapted to be worn during sleep. The garment includes one or more attachments and bears a coordinate indicia pattern, and orientation indicia that can correspond to an anatomical location of the patient such as a greater trocanter, a posterior superior iliac crest, a coccyx, an anterior ventral navel-aligned position, a medial or lateral patella border, a lateral or medial compartment of a respective inferior or superior knee joint, and a hamstring tendon, and combinations thereof. The sleep aid also includes a substantially compressible annular pad or pads formed with a generally toroidal or wedge-shaped cross section. The pads are configured to connect to the attachment near to the anatomical location to distribute the contact stress away from the symptomatic location and to surrounding tissues. The pad(s) also incorporate reference indicia adapted to cooperate with the coordinate indicia pattern to establish placement positions on the garment. The attachment may incorporate a hook and loop type fastener assembly and the pad(s) may be formed with generally tapered edges about inner and outer peripheries that circumscribe the annular portion of the pad(s).