发明申请
US20030220298A1 Combrestatin a-1 phosphate and combrestatin b-1 phosphate prodrugs
有权
Combrestatin a-1磷酸酯和combrestatin b-1磷酸酯前药
- 专利标题： Combrestatin a-1 phosphate and combrestatin b-1 phosphate prodrugs
- 专利标题（中）： Combrestatin a-1磷酸酯和combrestatin b-1磷酸酯前药
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申请号： US10258672申请日： 2002-10-25
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公开(公告)号： US20030220298A1公开(公告)日： 2003-11-27
- 发明人: George R. Pettit , John W. Lippert
- 主分类号： C07F009/22
- IPC分类号： C07F009/22 ; C07F009/28 ; A61K031/675
摘要：
The present invention relates to the syntheses and structural elucidation of Combretastatin A1-Phosphate Prodrugs and Combretastatin B1-Phosphate Prodrugs and the utilization of those prodrugs in the treatment of neoplastic diseases. The prodrugs described herein have the structure: Combretastin A-1 Phosphate Prodrug (I) and Combretastin B-1 Phosphate Prodrug (II). 1
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