The invention concerns a device for die-cutting a stack of sheet-like materials, particularly labels, whereby the stack is pressed into the die-cutter blade by a relative movement of a punching ram and a hollow cylindrical die-cutter blade. In such a device, a frame 16 with clamping elements 17 mounted in, and adjustable and lockable relative to the frame 16, is provided for fixation of the die-cutter blade 18, and also an adjusting element 70, 72 mounted in the frame 16 is provided for aligned orientation with a minimum of one orientation edge of the adjusting element 70, 72 with one knife edge section 69 of the die-cutter blade 18 prior to fixation of the adjusted clamping elements 17. Pre-adjustment of the die-cutter blade, for the purpose of optimal positioning to the stack to be punched, is ensured in a die-cutting device of this type.