发明申请
US20040092698A1 Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
失效
在生物系统中表现出增强的稳定性的衍生的聚氨酯组合物及其制备方法
- 专利标题: Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
- 专利标题(中): 在生物系统中表现出增强的稳定性的衍生的聚氨酯组合物及其制备方法
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申请号: US10672892申请日: 2003-09-26
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公开(公告)号: US20040092698A1公开(公告)日: 2004-05-13
- 发明人: Ivan Alferiev , Ilia Fishbein , Robert J. Levy
- 主分类号: C08G018/10
- IPC分类号: C08G018/10
摘要:
A process for preparing the polyurethane derivative, the process including: providing a polyurethane having a urethane amino moiety, providing a multifunctional linker reagent of a formula: LG-RL-(FG)n, wherein n is an integer from 1 to 3, FG is a functional group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, LG is a leaving group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, and RL is an (nnull1)-valent organic radical having at least one carbon atom; providing a protected thiol-containing reagent of a formula RnullC(O)SH, or a salt thereof, wherein R is a C1 to C6 alkyl group; reacting the multifunctional linker reagent with the urethane amino moiety to form a polyurethane substituted with at least one substituent group of a formula: nullRL-(FG)n; reacting the polyurethane with a protected thiol-containing reagent to form the polyurethane derivative.