发明申请
US20040131605A1 Precursor of N-acetylgalactosamine-4-sufatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
有权
N-乙酰半乳糖胺-4-磺化酶的前体，使用所述酶的处理方法以及所述酶的制备和纯化方法
- 专利标题： Precursor of N-acetylgalactosamine-4-sufatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
- 专利标题（中）： N-乙酰半乳糖胺-4-磺化酶的前体，使用所述酶的处理方法以及所述酶的制备和纯化方法
-
申请号： US10704365申请日： 2003-11-07
-
公开(公告)号： US20040131605A1公开(公告)日： 2004-07-08
- 发明人: Minmin Qin , Gary N. Zecherle , Wai-Pan Chan , Paul A. Fitzpatrick , Stuart Sweidler , John M. Henstrand , Dan J. Wendt , Lin Chen , Christopher M. Starr
- 申请人： BIOMARIN PHARMACEUTICAL INC.
- 申请人地址： US CA Novato
- 专利权人： BIOMARIN PHARMACEUTICAL INC.
- 当前专利权人： BIOMARIN PHARMACEUTICAL INC.
- 当前专利权人地址： US CA Novato
- 主分类号： A61K038/46
- IPC分类号： A61K038/46
摘要：
The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
公开/授权文献
信息查询
