This invention is related to an ink cleaning device, wherein this device comprises a cartridge stand, a driving mechanism, a printing control device and a cleaning cartridge. The feature of this invention is when the cleaning cartridge is put in the cartridge stand to replace the ink cartridge; the cleaning cartridge will be driven to guide cleanser into the guide tube and the printing head for cleaning purpose. Besides, the cartridge stand can accommodate the ink cartridge and the cleaning cartridge at one time. When ink cleaning function is required, the cleaning cartridge will be driven directly to clean the ink out by printing control device which is driven by an external device. The function of cleaning will also be approached.