发明申请
- 专利标题: Process for the preparation of azoxystrobin and analogues thereof
- 专利标题(中): 嘧菌酯及其类似物的制备方法
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申请号: US10480863申请日: 2004-06-09
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公开(公告)号: US20040242607A1公开(公告)日: 2004-12-02
- 发明人: David Anthony Jackson , James Peter Muxworthy , Mark Robert Sykes
- 优先权: GB0114408.8 20010613
- 主分类号: A61K031/513
- IPC分类号: A61K031/513 ; C07D239/02
摘要:
A process for the preparation of a compound of the general formula (I): wherein R1 is a 4-pyrimidinyl ring substituted at the 6-position by halo, hydroxy, 2-cyanophenoxy, 2,6-difluorophenoxy, 2-nitrophenoxy or 2-thiocarboxamidophenoxy and R2 is any group which can be transesterified to form a methyl ester, which comprises treating a compound of general formula (II): wherein R1 and R2 have the meanings given above, with a formylating agent and subsequently treating the formylated product with a methylating agent. 1
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