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发明申请
US20050002925A1 Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them 失效
来自具有高度保守基序的革兰氏阳性细菌的表面蛋白和识别它们的抗体

  • 专利标题： Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
  • 专利标题（中）： 来自具有高度保守基序的革兰氏阳性细菌的表面蛋白和识别它们的抗体
  • 申请号： US10911507
    申请日： 2004-08-05
  • 公开(公告)号： US20050002925A1
    公开(公告)日： 2005-01-06
  • 发明人: Yi Xu , Magnus Hook
  • 申请人： Yi Xu , Magnus Hook
  • 主分类号： A61K39/00
  • IPC分类号： A61K39/00 ;  C07K14/31 ;  C07K14/315 ;  C07K16/12 ;  A61K39/395
Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
摘要：
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface proteins of Gram-positive bacteria, and these consensus sequences include amino acid sequences such as LPXTG (SEQ ID NO:13), ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:14), VEGAVVEKPVAEAYLKQN (SEQ ID NO:15), and EYAGVDIDLAKKIAK (SEQ ID NO:16). By virtue of the highly conserved regions, the sequences and the proteins including these sequences can be utilized to generate antibodies which can recognize these highly conserved motifs and the proteins containing them and thus be useful in the treatment or prevention of a wide range of infections caused by Gram-positive bacteria.
摘要（中）：

提供了含有这些序列的分离的肽序列和蛋白质，其可用于预防和治疗由革兰氏阳性菌引起的感染。 已经显示肽序列在革兰氏阳性细菌的表面蛋白中是高度保守的基序，并且这些共有序列包括氨基酸序列，例如LPXTG（SEQ ID NO：13），ALKTGKIDIIISGMTSTPERKK（SEQ ID NO：14），VEGAVVEKPVAEAYLKQN （SEQ ID NO：15）和EYAGVDIDLAKKIAK（SEQ ID NO：16）。 由于高度保守的区域，包括这些序列的序列和蛋白质可用于产生能识别这些高度保守的基序和含有它们的蛋白质的抗体，因此可用于治疗或预防引起的广泛感染 通过革兰氏阳性菌。

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