- 专利标题: Pyrimidine compound and medicinal composition thereof
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申请号: US10492905申请日: 2002-10-22
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公开(公告)号: US20050004149A1公开(公告)日: 2005-01-06
- 发明人: Hitoshi Harada , Osamu Asano , Masato Ueda , Shuhei Miyazawa , Yoshihiko Kotake , Yasuhiro Kabasawa , Masahiro Yasuda , Nobuyuki Yasuda , Daisuke Iida , Junichi Nagakawa , Kazuo Hirota , Makoto Nakagawa
- 申请人: Hitoshi Harada , Osamu Asano , Masato Ueda , Shuhei Miyazawa , Yoshihiko Kotake , Yasuhiro Kabasawa , Masahiro Yasuda , Nobuyuki Yasuda , Daisuke Iida , Junichi Nagakawa , Kazuo Hirota , Makoto Nakagawa
- 优先权: JP2001-324018 20011022
- 国际申请: PCT/JP02/10952 WO 20021022
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; A61P1/00 ; A61P1/10 ; A61P3/04 ; A61P3/10 ; A61P9/12 ; A61P11/06 ; A61P13/02 ; A61P19/10 ; A61P25/16 ; A61P25/28 ; A61P43/00 ; C07D401/04 ; C07D405/14 ; C07D409/14 ; C07
摘要:
The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. In the formula, R1 and R2 are the same as or different from each other and each represents a hydrogen atom, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a cycloalkenyl group having three to eight carbon atoms which may be substituted, a 5 to 14-membered non-aromatic heterocyclic group which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, an acyl group having one to six carbon atoms which may be substituted or an alkylsulfonyl group having one to six carbon atoms which may be substituted; R3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, a nitrogen atom which may be substituted, an oxygen atom which may be substituted or a sulfur atom which may be substituted; R4 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted or a 5 to 14-membered non-aromatic heterocyclic group having at least one or more unsaturated bonds which may be substituted; and R5 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted or a 5 to 14-membered aromatic heterocyclic group which may be substituted.
公开/授权文献
- US07396836B2 Pyrimidine compound and medicinal composition thereof 公开/授权日:2008-07-08