发明申请
US20050004189A1 Thiazole compounds as integrin receptor antagonists derivatives
失效
噻唑化合物作为整合素受体拮抗剂衍生物
- 专利标题： Thiazole compounds as integrin receptor antagonists derivatives
- 专利标题（中）： 噻唑化合物作为整合素受体拮抗剂衍生物
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申请号： US10741056申请日： 2003-12-19
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公开(公告)号： US20050004189A1公开(公告)日： 2005-01-06
- 发明人: John Wendt , Heather Stenmark , Hongwei Wu , Yaping Wang , Barbara Chen , Thomas Penning , Victoria Downs , Mark Boys , Mark Russell , Dale Spangler
- 申请人： John Wendt , Heather Stenmark , Hongwei Wu , Yaping Wang , Barbara Chen , Thomas Penning , Victoria Downs , Mark Boys , Mark Russell , Dale Spangler
- 专利权人： Pharmacia Corporation
- 当前专利权人： Pharmacia Corporation
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; C07D471/04 ; C07D417/02 ; A61K31/426 ; A61K31/427
摘要：
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or the αvβ5 integrin without significantly inhibiting the αvβ6 integrin.