A system and method of detecting entangled photon pairs, each pair including a signal photon and an idler photon, is disclosed. Entangled photon pairs are provided having an entanglement time and an entanglement area selected to substantially increase an associated entangled two-photon cross-section of an associated target medium. The entangled photon pairs are also selected to have an energy distribution between the signal photon and the idler photon to substantially decrease an associated random two-photon absorption cross section of the target medium. The entangled photon pairs are directed to the target medium, and at least one entangled-photon pair being absorbed by the target medium is detected.