发明申请
US20050009852A1 7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates
失效
7,89,10-四氢-6h氮杂，6,7,8-9-四氢 - 吡啶并且2,3-二氢-2H-吡咯并[2,1-b] - 喹唑啉酮衍生物
![7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates](/docs/US/2005-01-13/US20050009852A1/abs.jpg.600x600.jpg)
- 专利标题： 7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates
- 专利标题（中）： 7,89,10-四氢-6h氮杂，6,7,8-9-四氢 - 吡啶并且2,3-二氢-2H-吡咯并[2,1-b] - 喹唑啉酮衍生物
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申请号： US10489350申请日： 2003-07-08
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公开(公告)号： US20050009852A1公开(公告)日： 2005-01-13
- 发明人: Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Siffelen , Thomas Weller
- 申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Siffelen , Thomas Weller
- 国际申请： PCT/EP03/07297 WO 20030708
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61K31/522 ; A61K45/00 ; A61P3/04 ; A61P9/00 ; A61P25/18 ; A61P25/20 ; A61P25/24 ; A61P35/00 ; A61P43/00 ; C07D471/04 ; C07D487/04
![7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates](/abs-image/US/2005/01/13/US20050009852A1/abs.jpg.150x150.jpg)
摘要：
The invention relates to novel 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2, 1-b]-quinazolinone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.