A computer enclosure includes a cage (10), a side panel (11) and a latch device (30) for securing the side panel to the cage. The cage includes a cutout (52) and a plurality of slits (26), the side panel includes a receiving portion (42) and a plurality of catches (12) for engaging in the slits. The latch device received in the receiving portion includes a cover (32), a base (34) combined with the cover, a handle (36) and a locking mechanism (38) placed in the base. The locking mechanism includes a pair of levers (70) and a resilient arm (80) connecting the levers. When the handle is pressed to deform the resilient arm, the levers are retracted towards each other, so that distal ends of the levers are in alignment with the cutout, the side panel is thus detachable from the cage.