The present invention provides a multi-piece solid golf ball having good shot feel, excellent flight performance and excellent controllability. The present invention relates to a multi-piece solid golf ball comprising a core composed of a center and at least one intermediate layer formed on the center, and a cover covering the core, wherein assuming that a central point hardness of the center, a surface hardness of the center, a hardness of the intermediate layer and a hardness of the cover in Shore D hardness are represented by HM, HS, HI and HC, respectively, the HM, HS, HI and HC satisfy a correlation represented by the following formulae: −5≦(HS−HM)≦5 HS