发明申请
US20050020585A1 Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
失效
代谢型谷氨酸受体-5的杂芳基取代三唑调节剂
- 专利标题: Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
- 专利标题(中): 代谢型谷氨酸受体-5的杂芳基取代三唑调节剂
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申请号: US10499391申请日: 2002-12-13
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公开(公告)号: US20050020585A1公开(公告)日: 2005-01-27
- 发明人: Nicholas Cosford , Petpiboon Prasit , Jeffrey Roppe , Nicholas Smith , Lida Tehrani
- 申请人: Nicholas Cosford , Petpiboon Prasit , Jeffrey Roppe , Nicholas Smith , Lida Tehrani
- 国际申请: PCT/US02/41720 WO 20021213
- 主分类号: A61K31/135
- IPC分类号: A61K31/135 ; A61K31/145 ; A61K31/185 ; A61K31/19 ; A61K31/195 ; A61K31/4439 ; A61K31/485 ; A61K31/506 ; A61K31/5513 ; A61K45/00 ; A61K45/06 ; A61P3/04 ; A61P3/12 ; A61P3/14 ; A61P21/00 ; A61P25/00 ; A61P25/04 ; A61P25/08 ; A61P25/14 ; A61P25/16 ; A61P25/18 ; A61P25/20 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P25/30 ; A61P29/00 ; C07D401/04 ; C07D401/14 ; A61K31/54 ; A61K31/4178 ; A61K31/4196 ; A61K31/454 ; A61K31/496 ; A61K31/5377
摘要:
Triazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl which are metabotropic glutamate receptor—subtype 5 (“mGluR5”) modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorder and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal and other diseases.
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