发明申请
- 专利标题: NF-kappaB inhibitors and uses thereof
- 专利标题(中): NF-κB抑制剂及其用途
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申请号: US10726411申请日: 2003-12-03
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公开(公告)号: US20050020586A1公开(公告)日: 2005-01-27
- 发明人: Jetze Tepe
- 申请人: Jetze Tepe
- 申请人地址: US MI East Lansing
- 专利权人: Board of Trustees of Michigan State University
- 当前专利权人: Board of Trustees of Michigan State University
- 当前专利权人地址: US MI East Lansing
- 主分类号: C07D233/22
- IPC分类号: C07D233/22 ; C07D233/28 ; C07D401/04 ; C07D403/06 ; A61K31/541 ; A61K31/4172 ; A61K31/4178 ; A61K31/454 ; A61K31/496 ; A61K31/5377 ; C07
摘要:
A new class of imidazolines as 4-position esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma, etc.), antibacterial agents, and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-kB as well as potent activity against the Gram (+) bacterium. The compositions are also useful for treating autoimmune diseases and for inhibiting rejection of organ and tissue transplants.
公开/授权文献
- US07528161B2 NF-kappaB inhibitors and uses thereof 公开/授权日:2009-05-05