发明申请
- 专利标题： Novel protein and processes for producing the same
- 专利标题（中）： 新型蛋白质及其生产方法
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申请号： US10900423申请日： 2004-07-28
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公开(公告)号： US20050026253A1公开(公告)日： 2005-02-03
- 发明人: Masaaki Goto , Akihiro Tomoyasu , Kazuki Yano , Fumie Kobayashi , Nobuaki Nakagawa , Hisataka Yasuda , Kyoji Yamaguchi , Masahiko Kinosaki , Shin-ichi Mochizuki , Tadashi Nakakarumai , Tomonori Morinaga , Eisuke Tsuda , Kanji Higashio
- 申请人： Masaaki Goto , Akihiro Tomoyasu , Kazuki Yano , Fumie Kobayashi , Nobuaki Nakagawa , Hisataka Yasuda , Kyoji Yamaguchi , Masahiko Kinosaki , Shin-ichi Mochizuki , Tadashi Nakakarumai , Tomonori Morinaga , Eisuke Tsuda , Kanji Higashio
- 申请人地址： JP Tokyo
- 专利权人： DAIICHI PHARMACEUTICAL CO., LTD.
- 当前专利权人： DAIICHI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： JP Tokyo
- 优先权： JP1998-243355 19980828; JP1998-99741 19980410
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/47 ; C12N5/08 ; C07H21/04
摘要：
A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a molecular weight of about 45 kD under non-reducing conditions and about 28 kD and/or 23 kD under reducing conditions, and exhibiting affinity to heparin. A process of producing the protein comprising culturing human fibroblasts and purifying the culture broth by chromatography using an ion exchange column, affinity column, and reverse phase column. A cDNA encoding the protein and a process of producing the protein using the cDNA are also provided. The protein of the present invention is useful as a pharmaceutical composition for preventing or treating obesity or as an antigen for establishing immunological diagnosis, etc.,
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