发明申请
- 专利标题： 3, 5 disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
- 专利标题（中）： 3,5-二取代吲唑化合物，药物组合物和介导或抑制细胞增殖的方法
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申请号： US10866059申请日： 2004-06-10
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公开(公告)号： US20050026960A1公开(公告)日： 2005-02-03
- 发明人: Susan Kephart , Indrawan McAlpine , Siegfried Reich
- 申请人： Susan Kephart , Indrawan McAlpine , Siegfried Reich
- 专利权人： AGOURON PHARMACEUTICALS, INC.
- 当前专利权人： AGOURON PHARMACEUTICALS, INC.
- 主分类号： A61K31/416
- IPC分类号： A61K31/416 ; A61P35/00 ; C07D401/14 ; C07D413/04 ; A61K31/4439 ; C07
摘要：
3,5 disubstituted indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
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