发明申请
US20050026963A1 Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
有权
代谢型谷氨酸受体-5的杂芳基取代的吡唑调节剂
- 专利标题： Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
- 专利标题（中）： 代谢型谷氨酸受体-5的杂芳基取代的吡唑调节剂
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申请号： US10497122申请日： 2002-12-13
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公开(公告)号： US20050026963A1公开(公告)日： 2005-02-03
- 发明人: Nicholas Cosford , Chixu Chen , Brian Eastman , Dehua Huang , Benito Munoz , Petpiboon Prasit , Nicholas Smith
- 申请人： Nicholas Cosford , Chixu Chen , Brian Eastman , Dehua Huang , Benito Munoz , Petpiboon Prasit , Nicholas Smith
- 国际申请： PCT/US02/40147 WO 20021213
- 主分类号： A61K31/4155
- IPC分类号： A61K31/4155 ; A61K31/424 ; A61K31/427 ; A61K31/4439 ; A61K31/444 ; A61K31/4709 ; A61K31/497 ; A61K31/498 ; A61K31/506 ; A61K45/00 ; A61P3/04 ; A61P17/06 ; A61P21/00 ; A61P25/04 ; A61P25/08 ; A61P25/14 ; A61P25/16 ; A61P25/18 ; A61P25/20 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P25/30 ; A61P25/34 ; A61P29/00 ; A61P43/00 ; C07D231/38 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D403/14 ; C07D413/04 ; C07D413/14 ; C07D417/04
摘要：
Pyrazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorder and panic, as well as in the treatment of pain, circadian rhythm disorders, and other diseases.