发明申请
US20050027126A1 Processes for preparing zonisamide intermediates and novel crystalline forms of zonisamide intermediates
审中-公开
制备唑尼沙胺中间体和新型结晶形式的唑胺中间体的方法
- 专利标题： Processes for preparing zonisamide intermediates and novel crystalline forms of zonisamide intermediates
- 专利标题（中）： 制备唑尼沙胺中间体和新型结晶形式的唑胺中间体的方法
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申请号： US10928313申请日： 2004-08-30
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公开(公告)号： US20050027126A1公开(公告)日： 2005-02-03
- 发明人: Tamar Nidam , Marioara Mendelovici , Eduard Schwartz , Shlomit Wizel
- 申请人： Tamar Nidam , Marioara Mendelovici , Eduard Schwartz , Shlomit Wizel
- 主分类号： C07D261/20
- IPC分类号： C07D261/20 ; C07D207/444
摘要：
The present invention relates to a novel sulfonation of an intermediate of zonisamide. The sulfonation processes using chlorosulfonic acid as well as acetic anhydride and sulfuric acid in an organic solvent are disclosed. Crystalline forms of benzisoxazole methane sulfonic acid (BOS-H) and its salts (BOS-Na, BOS-Ca, and BOS-Ba) and their novel preparation processes are disclosed.
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