The present invention provides a machine tool capable of reducing residual vibration occurring at the location time, thereby achieving responsiveness to a recent demand for higher acceleration/deceleration speed. The machine tool is configured such that a column 3 is fixed on a bed 2, a spindle head 6 for supporting a spindle 7 is disposed on a front face 3b′ of the column 3 to be movable in a Z-axis direction, and a pair of right and left Z-axis ball screws (spindle drive shafts) 22 for driving the vicinity of the gravity center of the spindle head 6 is disposed on the front face 3b′ of the column 3 to be symmetrical to each other with respect to a plane that includes an axis C of the spindle head 6 and is parallel to a Y axis, thereby driving the vicinity of the gravity center of the spindle head 6.