发明申请
US20050032868A1 Selected substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
审中-公开
所选取代的吡唑衍生物和相关化合物作为缓激肽B1受体拮抗剂
- 专利标题： Selected substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
- 专利标题（中）： 所选取代的吡唑衍生物和相关化合物作为缓激肽B1受体拮抗剂
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申请号： US10836903申请日： 2004-04-30
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公开(公告)号： US20050032868A1公开(公告)日： 2005-02-10
- 发明人: Albert Garofalo , Jay Tung , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
- 申请人： Albert Garofalo , Jay Tung , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
- 主分类号： A61K31/4152
- IPC分类号： A61K31/4152 ; A61K31/416 ; C07D231/16 ; C07D231/40 ; C07D401/12 ; C07D403/12 ; C07D417/12 ; C07D43/02
摘要：
Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.