A method for calibrating tilt control values of a PUH in real time is applied to an optical disk drive and includes the steps of: creating a look-up table, the look-up table including several optical disk data/physical addresses of track zones and the corresponding tilt control values; reading tilt control values as reference values from the look-up table corresponding the track position of a PUH; calculating a current tilt control value according to the reference values; controlling the PUH according to the current tilt control value; reading a decoding error generated during a decoding procedure of the optical disk drive; calibrating the tilt control values and updating the look-up table. When the decoding error is larger than a decoding error threshold, the tilt control values of the track zone is calibrated. Hence, even an irregularly deformed optical disk can be calibrated to obtain better tilt control values.