发明申请
- 专利标题： Antisense modulation of stearoyl-CoA desaturase expression
- 专利标题（中）： 硬脂酰-CoA去饱和酶表达的反义调制
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申请号： US10619253申请日： 2003-07-15
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公开(公告)号： US20050043256A1公开(公告)日： 2005-02-24
- 发明人: Rosanne Crooke , Mark Graham
- 申请人： Rosanne Crooke , Mark Graham
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K45/06 ; C07H20060101 ; C12N9/02 ; C12N15/113 ; A61K48/00 ; C07H21/02
摘要：
Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.