发明申请
- 专利标题: Novel diterpene compounds
- 专利标题(中): 新型二萜化合物
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申请号: US10767436申请日: 2004-01-30
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公开(公告)号: US20050043549A1公开(公告)日: 2005-02-24
- 发明人: Susumu Kitanaka , Syohei Miyata , Liyan Wang , Naili Wang , Xinsheng Yao
- 申请人: Susumu Kitanaka , Syohei Miyata , Liyan Wang , Naili Wang , Xinsheng Yao
- 申请人地址: JP Tokyo
- 专利权人: NIHON UNIVERSITY
- 当前专利权人: NIHON UNIVERSITY
- 当前专利权人地址: JP Tokyo
- 优先权: JP2003-201340 20030724
- 主分类号: C07D493/08
- IPC分类号: C07D493/08 ; A61K31/34 ; A61P35/00 ; C07D493/04
摘要:
The present invention provides a novel diterpene compounds with antineoplastic activities. The novel diterpene compounds of the present invention are represented by the general formula (I). R1 to R6 in the formula represent an aliphatic group, or a radical represented by the general formula RCO—, wherein R represents an aliphatic, an aromatic or a heteroaromatic group. The compounds of the present invention may be prepared by extracting roots of Euphorbia kansui L. with an organic solvent such as chloroform, ethyl acetate and butanol. These extracted compounds may be used as starting materials for the preparation of the compounds represented by the general formula (I). The compounds of the present invention have antineoplastic activities, and therefore, useful as antineoplastic agents.
公开/授权文献
- US07009061B2 Diterpene compounds 公开/授权日:2006-03-07