发明申请
US20050048066A1 Identification of potential immunodominant acetylcholine receptor alpha subunit
审中-公开
鉴定潜在的免疫显性乙酰胆碱受体α亚基
- 专利标题： Identification of potential immunodominant acetylcholine receptor alpha subunit
- 专利标题（中）： 鉴定潜在的免疫显性乙酰胆碱受体α亚基
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申请号： US10240035申请日： 2001-03-30
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公开(公告)号： US20050048066A1公开(公告)日： 2005-03-03
- 发明人: Shrikant Deshpande , Edward Spack , Nancy Wehner , Subhashini Arimilli
- 申请人： Shrikant Deshpande , Edward Spack , Nancy Wehner , Subhashini Arimilli
- 国际申请： PCT/US01/10450 WO 20010330
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K39/00 ; A61P21/04 ; A61P37/00 ; A61P37/06 ; C07K7/08 ; C07K14/705 ; C07K14/74 ; C07K19/00
摘要：
The present invention is directed to the treatment of autoimmune diseases, in particular of Myasthenia Gravis. This invention provides novel autoimmune dominant peptides derived from the acetylcholine receptor, as well as methods for preparing the peptides. The present invention further provides complexes comprising these peptides associated with an appropriate major histocompatibility complex (MHC) molecule and methods for making these complexes. The complexes of the present invention can be used therapeutically or prophylactically for treating Myasthenia Gravis.
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