发明申请
- 专利标题: Nitrogenous heterocyclic derivative, medicinal composition containing the same, medical use thereof, and intermediate therefor
- 专利标题(中): 含氮杂环衍生物,含有它们的药物组合物,其医疗用途及其中间体
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申请号: US10481013申请日: 2002-06-17
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公开(公告)号: US20050049203A1公开(公告)日: 2005-03-03
- 发明人: Toshihiro Nishimura , Hideki Fujikura , Nobuhiko Fushimi , Kazuya Tatani , Kenji Katsuno , Masayuki Isaji
- 申请人: Toshihiro Nishimura , Hideki Fujikura , Nobuhiko Fushimi , Kazuya Tatani , Kenji Katsuno , Masayuki Isaji
- 优先权: JP2001-187368 20010620
- 国际申请: PCT/JP02/06000 WO 20020617
- 主分类号: A61P3/04
- IPC分类号: A61P3/04 ; A61P3/10 ; A61P43/00 ; C07H17/02 ; A61K31/7052
摘要:
The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 and X3 independently represent N or CH; X2 represents N or CR2; X4 represents N or CR3; and with the proviso that one or two of X1, X2, X3 and X4 represent N; R1 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted(lower alkoxy) group, a lower alkoxy(lower alkoxy) -substituted (lower alkyl) group, a cyclic lower alkyl group, a halo(lower alkyl) group or a group represented by the general formula: HO-A—wherein A represents a lower alkylene group, a lower alkyleneoxy group or a lower alkylenethio group; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a cyclic lower alkyl group, a lower alkoxy group, an amino group, a (lower acyl)amino group, a mono(lower alkyl)amino group or a di(lower alkyl)amino group; and R3 represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, or prodrugs thereof which are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutical compositions comprising the same, and pharmaceutical uses and production intermediates thereof.