发明申请
US20050053970A1 Methods and compositions for identifying peptide aptamers capable of altering a cell phenotype
审中-公开
用于鉴定能够改变细胞表型的肽适体的方法和组合物
- 专利标题： Methods and compositions for identifying peptide aptamers capable of altering a cell phenotype
- 专利标题（中）： 用于鉴定能够改变细胞表型的肽适体的方法和组合物
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申请号： US10833951申请日： 2004-04-28
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公开(公告)号： US20050053970A1公开(公告)日： 2005-03-10
- 发明人: John Benson , Sylvie Vincent , Bradley Brasher , Zhenwei Miao , Dudley Lamming
- 申请人： John Benson , Sylvie Vincent , Bradley Brasher , Zhenwei Miao , Dudley Lamming
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07K14/435 ; C12N15/10 ; C12N15/867 ; C12Q1/68 ; G01N33/50 ; G01N33/68
摘要：
The invention provides methods and compositions for screening and identifying of peptide aptamers that can modulate a cell phenotype and further, can be used for the treatment of a disease involving a misregulated cell phenotype, such as, for example, a cancer. The invention encompasses methods and compositions for producing cyclic peptide aptamers, including peptide aptamers comprising a conotoxin sequence, having improved stability and bioactivity. The invention also provides methods and compositions for improved gene delivery and expression of a peptide aptamer in cell.
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